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1

Glycogen Synthase Kinase 3β Inhibition and βcatenin Activation Contribute to Enhanced Survival After Radiation in Pancreatic Cancer Cells

Spalding, A., Watson, R.L., Zielske, S.P., Kim, A., Bommer, G., Fearon, E.R., Eldar-Finkelman, H., Lawrence, T.S., Ben-Josef, E.

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2007

Language:

english

File:

PDF, 42 KB

english, 2007

2

Substrate Competitive GSK-3 Inhibitors strategy and Implications

Hagit Eldar-Finkelman, Avital Licht-Murava, Shmuel Pietrokovski, Miriam Eisenstein

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2010

Language:

english

File:

PDF, 696 KB

english, 2010

3

Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide

Adi Shruster, Hagit Eldar-Finkelman, Eldad Melamed, Daniel Offen

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 507 KB

english, 2011

4

Nuclear GSK-3β inhibits the canonical Wnt signalling pathway in a β-catenin phosphorylation-independent manner

Caspi, M, Zilberberg, A, Eldar-Finkelman, H, Rosin-Arbesfeld, R

Journal:

Year:

2008

Language:

english

File:

PDF, 321 KB

english, 2008

5

Lithium-mediated phosphorylation of glycogen synthase kinase-3β involves PI3 kinase-dependent activation of protein kinase C-α

Noa Kirshenboim, Batya Plotkin, Shani Ben Shlomo, Oksana Kaidanovich-Beilin, Hagit Eldar-Finkelman

Journal:

Journal of Molecular Neuroscience

Year:

2004

Language:

english

File:

PDF, 270 KB

english, 2004

6

Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: An fast and atom efficient access to 1-aryl-3-benzylureas

Fabio Lo Monte, Thomas Kramer, Alexander Boländer, Batya Plotkin, Hagit Eldar-Finkelman, Ana Fuertes, Juan Dominguez, Boris Schmidt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 682 KB

english, 2011

7

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

Lina Tsaadon Alon, Shmuel Pietrokovski, Shay Barkan, Limor Avrahami, Oksana Kaidanovich-Beilin, James R. Woodgett, Anat Barnea, Hagit Eldar-Finkelman

Journal:

Year:

2011

Language:

english

File:

PDF, 484 KB

english, 2011

8

Profile: GSK-3 inhibitors: potential drugs for neurodegenerative disorders

David Gurwitz, Hagit Eldar-Finkelman

Journal:

Drug Discovery Today

Year:

2001

Language:

english

File:

PDF, 86 KB

english, 2001

9

New Insights into the Autoinhibition Mechanism of Glycogen Synthase Kinase-3β

Ronit Ilouz, Shmuel Pietrokovski, Miriam Eisenstein, Hagit Eldar-Finkelman

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1017 KB

english, 2008

10

Role of glycogen synthase kinase-3β in early depressive behavior induced by mild traumatic brain injury

Moran Shapira, Avital Licht, Anat Milman, Chaim G. Pick, Esther Shohami, Hagit Eldar-Finkelman

Journal:

Molecular and Cellular Neuroscience

Year:

2007

Language:

english

File:

PDF, 729 KB

english, 2007

11

Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3

Racheli Karyo, Yael Eskira, Albert Pinhasov, RH Belmaker, Galila Agam, Hagit Eldar-Finkelman

Journal:

Molecular and Cellular Neuroscience

Year:

2010

Language:

english

File:

PDF, 687 KB

english, 2010

12

Inhibition of glycogen synthase kinase-3β by bivalent zinc ions: insight into the insulin-mimetic action of zinc

Ronit Ilouz, Oksana Kaidanovich, David Gurwitz, Hagit Eldar-Finkelman

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 173 KB

english, 2002

13

Glycogen synthase kinase 3: an emerging therapeutic target

Hagit Eldar-Finkelman

Journal:

Trends in Molecular Medicine

Year:

2002

Language:

english

File:

PDF, 394 KB

english, 2002

14

Elucidating Substrate and Inhibitor Binding Sites on the Surface of GSK-3β and the Refinement of a Competitive Inhibitor

Avital Licht-Murava, Batya Plotkin, Miriam Eisenstein, Hagit Eldar-Finkelman

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.30 MB

english, 2011

15

Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on β-catenin in mouse hippocampus

Oksana Kaidanovich-Beilin, Anat Milman, Abraham Weizman, Chaim G Pick, Hagit Eldar-Finkelman

Journal:

Biological Psychiatry

Year:

2004

Language:

english

File:

PDF, 147 KB

english, 2004

16

Inhibition of Glycogen Synthase Kinase-3 Ameliorates -Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model: IN VIVO AND IN VITRO STUDIES

Avrahami, L., Farfara, D., Shaham-Kol, M., Vassar, R., Frenkel, D., Eldar-Finkelman, H.

Journal:

Journal of Biological Chemistry

Year:

2013

Language:

english

File:

PDF, 2.50 MB

english, 2013

17

Structure-based optimization of oxadiazole-based GSK-3 inhibitors

Lo Monte, Fabio, Kramer, Thomas, Gu, Jiamin, Brodrecht, Martin, Pilakowski, Johannes, Fuertes, Ana, Dominguez, Juan Manuel, Plotkin, Batya, Eldar-Finkelman, Hagit, Schmidt, Boris

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.23 MB

english, 2013

18

Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4- e ]pyrrolo[3,4- g ]indolizine-4,6(1 H ,5 H )-diones as New Glycogen Synthase Kinase-3β Inhibitors

La Pietra, Valeria, La Regina, Giuseppe, Coluccia, Antonio, Famiglini, Valeria, Pelliccia, Sveva, Plotkin, Batya, Eldar-Finkelman, Hagit, Brancale, Andrea, Ballatore, Carlo, Crowe, Alex, Brunden, Kurt

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1023 KB

english, 2013

19

GSK3β and β-Catenin Modulate Radiation Cytotoxicity in Pancreatic Cancer

Watson, Richard L., Spalding, Aaron C., Zielske, Steven P., Morgan, Meredith, Kim, Alex C., Bommer, Guido T., Eldar-Finkelman, Hagit, Giordano, Thomas, Fearon, Eric R., Hammer, Gary D., Lawrence, Theo

Journal:

Year:

2010

Language:

english

File:

PDF, 1.72 MB

english, 2010

20

GSK-3 inhibition: Achieving moderate efficacy with high selectivity

Avrahami, Limor, Licht-Murava, Avital, Eisenstein, Miriam, Eldar-Finkelman, Hagit

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2013

Language:

english

File:

PDF, 323 KB

english, 2013

21

Expression and Characterization of Glycogen Synthase Kinase-3 Mutants and their Effect on Glycogen Synthase Activity in Intact Cells

Hagit Eldar-Finkelman, Gretchen M. Argast, Orit Foord, Edmond H. Fischer and Edwin G. Krebs

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.67 MB

english, 1996

22

Phosphorylation of Insulin Receptor Substrate 1 by Glycogen Synthase Kinase 3 Impairs Insulin Action

Hagit Eldar-Finkelman and Edwin G. Krebs

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 1.30 MB

english, 1997

23

Challenges and opportunities with glycogen synthase kinase-3 inhibitors for insulin resistance and Type 2 diabetes treatment

Eldar-Finkelman, Hagit, Ilouz, Ronit

Journal:

Expert Opinion on Investigational Drugs

Year:

2003

Language:

english

File:

PDF, 181 KB

english, 2003

24

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice

Eldar-Finkelman, H., Schreyer, S. A., Shinohara, M. M., LeBoeuf, R. C., Krebs, E. G.

Journal:

Year:

1999

Language:

english

File:

PDF, 327 KB

english, 1999

25

The role of glycogen synthase kinase-3 in insulin resistance and Type 2 diabetes

Eldar-Finkelman, Hagit, Kaidanovich, Oksana

Journal:

Expert Opinion on Therapeutic Targets

Year:

2002

Language:

english

File:

PDF, 230 KB

english, 2002

26

Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth

Azoulay-Alfaguter, I, Elya, R, Avrahami, L, Katz, A, Eldar-Finkelman, H

Journal:

Year:

2014

Language:

english

File:

PDF, 2.40 MB

english, 2014

27

GSK-3 and lysosomes meet in Alzheimer’s disease

Avrahami, Limor, Eldar-Finkelman, Hagit

Journal:

Communicative & Integrative Biology

Year:

2013

Language:

english

File:

PDF, 145 KB

english, 2013

28

Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3

Beurel, E., Kaidanovich-Beilin, O., Yeh, W.-I., Song, L., Palomo, V., Michalek, S. M., Woodgett, J. R., Harrington, L. E., Eldar-Finkelman, H., Martinez, A., Jope, R. S.

Journal:

The Journal of Immunology

Year:

2013

Language:

english

File:

PDF, 2.29 MB

english, 2013

29

Identification of Novel Glycogen Synthase Kinase-3β Substrate-interacting Residues Suggests a Common Mechanism for Substrate Recognition

Ilouz, Ronit, Kowalsman, Noga, Eisenstein, Miriam, Eldar-Finkelman, Hagit

Journal:

Journal of Biological Chemistry

Year:

2006

Language:

english

File:

PDF, 1.02 MB

english, 2006

30

Upregulation of Glucose Metabolism During Intimal Lesion Formation Is Coupled to the Inhibition of Vascular Smooth Muscle Cell Apoptosis: Role of GSK3

Hall, J. L., Chatham, J. C., Eldar-Finkelman, H., Gibbons, G. H.

Journal:

Year:

2001

Language:

english

File:

PDF, 222 KB

english, 2001

31

Glycogen synthase kinase 3 mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1

Leng, S., Zhang, W., Zheng, Y., Liberman, Z., Rhodes, C. J., Eldar-Finkelman, H., Sun, X. J.

Journal:

Journal of Endocrinology

Year:

2010

Language:

english

File:

PDF, 248 KB

english, 2010

32

The SIL Gene Is Essential for Mitotic Entry and Survival of Cancer Cells

Erez, A., Castiel, A., Trakhtenbrot, L., Perelman, M., Rosenthal, E., Goldstein, I., Stettner, N., Harmelin, A., Eldar-Finkelman, H., Campaner, S., Kirsch, I., Izraeli, S.

Journal:

Cancer Research

Year:

2007

Language:

english

File:

PDF, 680 KB

english, 2007

33

Distinct Molecular Regulation of Glycogen Synthase Kinase-3 Isozyme Controlled by Its N-terminal Region: FUNCTIONAL ROLE IN CALCIUM/CALPAIN SIGNALING

Azoulay-Alfaguter, I., Yaffe, Y., Licht-Murava, A., Urbanska, M., Jaworski, J., Pietrokovski, S., Hirschberg, K., Eldar-Finkelman, H.

Journal:

Journal of Biological Chemistry

Year:

2011

Language:

english

File:

PDF, 3.14 MB

english, 2011

34

Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 Cells

Eldar-Finkelman, H., Seger, R., Vandenheede, J. R., Krebs, E. G.

Journal:

Journal of Biological Chemistry

Year:

1995

File:

PDF, 2.59 MB

1995

35

Serine 332 Phosphorylation of Insulin Receptor Substrate-1 by Glycogen Synthase Kinase-3 Attenuates Insulin Signaling

Liberman, Ziva, Eldar-Finkelman, Hagit

Journal:

Journal of Biological Chemistry

Year:

2005

Language:

english

File:

PDF, 751 KB

english, 2005

36

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

Eldar-Finkelman, Hagit, Martinez, Ana

Journal:

Frontiers in Molecular Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.52 MB

english, 2011

37

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

Sharfi, H., Eldar-Finkelman, H.

Journal:

AJP Endocrinology and Metabolism

Year:

2007

Language:

english

File:

PDF, 1023 KB

english, 2007

38

Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C II in the diabetic fat tissue

Liberman, Z., Plotkin, B., Tennenbaum, T., Eldar-Finkelman, H.

Journal:

AJP Endocrinology and Metabolism

Year:

2008

Language:

english

File:

PDF, 871 KB

english, 2008

39

GSK-3� Inhibition Affects Singing Behavior and Neurogenesis in Adult Songbirds

Aloni, Etay, Shapira, Moran, Eldar-Finkelman, Hagit, Barnea, Anat

Journal:

Brain Behavior and Evolution

Year:

2015

Language:

english

File:

PDF, 256 KB

english, 2015

40

Peptide Inhibitors Targeting Protein Kinases

Eldar-Finkelman, Hagit, Eisenstein, Miriam

Journal:

Current Pharmaceutical Design

Year:

2009

Language:

english

File:

PDF, 300 KB

english, 2009

41

Exploiting Substrate Recognition for Selective Inhibition of Protein Kinases

Licht-Murava, Avital, Eldar-Finkelman, Hagit

Journal:

Current Pharmaceutical Design

Year:

2012

Language:

english

File:

PDF, 567 KB

english, 2012

42

Regulation of Ribosomal S6 Protein Kinase-p90 rsk , Glycogen Synthase Kinase 3, and β-Catenin in Early Xenopus Development

Torres, Monica A., Eldar-Finkelman, Hagit, Krebs, Edwin G., Moon, Randall T.

Journal:

Molecular and Cellular Biology

Year:

1999

Language:

english

File:

PDF, 1.44 MB

english, 1999

43

Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition

Grieco, Steven F., Cheng, Yuyan, Eldar-Finkelman, Hagit, Jope, Richard S., Beurel, Eléonore

Journal:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Year:

2016

Language:

english

File:

PDF, 565 KB

english, 2016

44

Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3

Grieco, Steven F., Velmeshev, Dmitry, Magistri, Marco, Eldar-Finkelman, Hagit, Faghihi, Mohammad A., Jope, Richard S., Beurel, Eleonore

Journal:

The World Journal of Biological Psychiatry

Year:

2016

Language:

english

File:

PDF, 1.64 MB

english, 2016

45

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

Licht-Murava, A., Paz, R., Vaks, L., Avrahami, L., Plotkin, B., Eisenstein, M., Eldar-Finkelman, H.

Journal:

Science Signaling

Year:

2016

Language:

english

File:

PDF, 8.95 MB

english, 2016

46

Increased glucose uptake promotes oxidative stress and PKC-δ activation in adipocytes of obese, insulin-resistant mice

Talior, Ilana, Yarkoni, Merav, Bashan, Nava, Eldar-Finkelman, Hagit

Journal:

American Journal of Physiology-Endocrinology and Metabolism

Year:

2003

Language:

english

File:

PDF, 305 KB

english, 2003

47

Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.

Eldar-Finkelman, H., Argast, G. M., Foord, O., Fischer, E. H., Krebs, E. G.

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.66 MB

english, 1996

48

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

Eldar-Finkelman, H., Krebs, E. G.

Journal:

Proceedings of the National Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 549 KB

english, 1997

49

GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways

Avrahami, Limor, Paz, Rom, Dominko, Kristina, Hecimovic, Silva, Bucci, Cecilia, Eldar-Finkelman, Hagit

Journal:

Cellular Signalling

Year:

2020

Language:

english

File:

PDF, 14.63 MB

english, 2020

50

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

Rippin, Ido, Khazanov, Netaly, Ben Joseph, Shirley, Kudinov, Tania, Berent, Eva, Arciniegas Ruiz, Sara Melisa, Marciano, Daniele, Levy, Laura, Gruzman, Arie, Senderowitz, Hanoch, Eldar-Finkelman, Hagi

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 4.43 MB

2020